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The effect of Y145C mutation in AHCY-1 on the total proteome of young adults C.elegans

ABSTRACT: Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model with increased SAH levels through pathogenic mutation in the S-adenosylhomocysteine hydrolase (AHCY-1), which impairs SAH hydrolysis to adenosine and homocysteine. This submission contains results of the quantitative (TMT) measurements of the proteins in whole worm extracts originated from AHCY-1 Y143C mutant (equivalent to the human pathogenic variant) and control worms.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Remigiusz Serwa

LAB HEAD: Wojciech Pokrzywa

PROVIDER: PXD041645 | Pride | 2023-09-29

REPOSITORIES: Pride

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			Action	DRS
	WP_TFA_fr1.raw	Raw
	WP_TFA_fr2.raw	Raw
	WP_TFA_fr3.raw	Raw
	WP_TFA_fr4.raw	Raw
	WP_TFA_fr5.raw	Raw

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