Dataset Information

The proteome analysis of Human colorectal cancer

ABSTRACT: Every three samples of pelvic CRC (DLD-1 clone#1-Luc cell) in the control and Chemically-modified miR-143 (CM-miR143) groups, which were frozen in liquid nitrogen, were prepared. Every three samples were resected four times, three days after the administration of the control miRNA or CM-miR143 lipoplexes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Jun Arima

LAB HEAD: Kohei Taniguchi

PROVIDER: PXD041937 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation.

Arima Jun J Taniguchi Kohei K Sugito Nobuhiko N Heishima Kazuki K Tokumaru Yoshihisa Y Inomata Yosuke Y Komura Kazumasa K Tanaka Tomohito T Shibata Masa-Aki MA Lee Sang-Woong SW Akao Yukihiro Y

Molecular therapy. Nucleic acids 20231115

Replenishing tumor-suppressor miRNAs (TS-miRNAs) is a potential next-generation nucleic acid-based therapeutic approach. Establishing an effective miRNA delivery system is essential to successful TS-miRNA therapy. To overcome vulnerability to RNA nucleases, we previously developed a chemically modified miRNA143-3p (CM-miR-143). In clinical practice, colorectal cancer (CRC) pelvic recurrence is an occasional challenge following curative resection, requiring a novel therapy because reoperative sur ...[more]

PMID: 38213952

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