Proteomics

Dataset Information

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Phosphatidylinositol 3-phosphate (PI3P) interactome analysis under varied iron conditions in Candida glabrata.


ABSTRACT: The project is aimed at identifying proteins that interact with PI3P in low-iron, regular-iron and high-iron grown Candida glabrata cells.

INSTRUMENT(S): LTQ Orbitrap Velos Pro

ORGANISM(S): Candida Glabrata (yeast) (torulopsis Glabrata)

SUBMITTER: Rupinder Kaur  

LAB HEAD: Rupinder Kaur

PROVIDER: PXD042058 | Pride | 2024-02-19

REPOSITORIES: Pride

Dataset's files

Source:
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Publications

Phosphatidylinositol 3-phosphate regulates iron transport via PI3P-binding CgPil1 protein.

Askari Fizza F   Vasavi Bhogadi B   Kaur Rupinder R  

Cell reports 20230724 8


Iron homeostasis, which is pivotal to virulence, is regulated by the phosphatidylinositol 3-kinase CgVps34 in the human fungal pathogen Candida glabrata. Here, we identify CgPil1 as a phosphatidylinositol 3-phosphate (PI3P)-binding protein and unveil its role in retaining the high-affinity iron transporter CgFtr1 at the plasma membrane (PM), with PI3P negatively regulating CgFtr1-CgPil1 interaction. PI3P production and its PM localization are elevated in the high-iron environment. Surplus iron a  ...[more]

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