Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Retina
SUBMITTER: Jillian Pearring
LAB HEAD: Jillian N. Pearring
PROVIDER: PXD042270 | Pride | 2023-10-24
REPOSITORIES: Pride
Items per page: 1 - 5 of 9 |
Nature communications 20230913 1
The primary cilium is a signaling organelle with a unique membrane composition maintained by a diffusional barrier residing at the transition zone. Many transition zone proteins, such as the tectonic complex, are linked to preserving ciliary composition but the mechanism remains unknown. To understand tectonic's role, we generate a photoreceptor-specific Tctn1 knockout mouse. Loss of Tctn1 results in the absence of the entire tectonic complex and associated MKS proteins yet has minimal effects o ...[more]