Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Cystic Fibrosis
SUBMITTER: Naoto Soya
LAB HEAD: Gergely L. Lukacs
PROVIDER: PXD042481 | Pride | 2024-01-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
ABCC6_NBD1-WT_MSMS.msf | Msf | |||
ABCC6_NBD1_F713G.zip | Other | |||
ABCC6_NBD1_F713G_MSMS.msf | Msf | |||
ABCC6_NBD1_WT.zip | Other | |||
CFTR_NBD1_6SS-WT_Nep2-Pep_digestion.zip | Other |
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Soya Naoto N Xu Haijin H Roldan Ariel A Yang Zhengrong Z Ye Haoxin H Jiang Fan F Premchandar Aiswarya A Veit Guido G Cole Susan P C SPC Kappes John J Hegedüs Tamás T Lukacs Gergely L GL
Nature communications 20231027 1
The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2) and transmembrane domains (TMD1,2). Using molecular dynamic simulations, biochemical and hydrogen deuterium exchange approaches, we show that the mutational uncoupling or stabilization of NBD1-TMD1/2 interfaces can compromise or facilitat ...[more]