Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Maike Krause
LAB HEAD: Giulia Quattrocolo
PROVIDER: PXD042517 | Pride | 2024-05-24
REPOSITORIES: Pride
Glærum Ingvild Lynneberg IL Dunville Keagan K Moan Kristian K Krause Maike M Montaldo Nicola Pietro NP Kirikae Hinako H Nigro Maximiliano Jose MJ Sætrom Pål P van Loon Barbara B Quattrocolo Giulia G
Development (Cambridge, England) 20240109 1
Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. To understand how the persistence of CR cells influences the maturation of hippocampal circuits, we combined a specific transgenic mouse line with viral vector injection to selectively ablate CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. In addition, transcriptomic analysis highlighted significant changes ...[more]