Differential MAPK Phosphorylation of Connexin43
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human)
SUBMITTER: 
Jason Conage-Pough
LAB HEAD: Forest Michael White
PROVIDER: PXD042575 | Pride | 2025-01-14
REPOSITORIES: pride
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Publications
Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward connexin 43.
Latchford Lauren P LP Perez Liz S LS Conage-Pough Jason E JE Turk Reem R Cusimano Marissa A MA Vargas Victoria I VI Arora Sonal S Shienvold Sophia R SR Kulp Ryan R RR Belverio Hailey M HM White Forest M FM Thévenin Anastasia F AF
The Journal of biological chemistry 20250110 3
Phosphorylation of connexin 43 (Cx43) is an important regulatory mechanism of gap junction (GJ) function. Cx43 is modified by several kinases on over 15 sites within its ∼140 amino acid-long C-terminus (CT). Phosphorylation of Cx43CT on S255, S262, S279, and S282 by ERK has been widely documented in several cell lines, by many investigators. Phosphorylation of these sites by JNK and p38, on the other hand, is not well-established. Indeed, ERK is a kinase activated by growth factors and is upregu ...[more]
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