Dataset Information

ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation

ABSTRACT: This study aims to elucidate potential functions of the editing-deficient ADAR3 enzyme in Mouse. This dataset aims to investigate the binding partners of the ADAR3 enzyme, both with and without RNAse treatment in order to differentiate between RNA dependent and independent interactions. The control is a Co-IP of a FLAG-tagged Luciferase protein.

INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Neuroblast Development, Neuron

DISEASE(S): Brain Disease

SUBMITTER: Charlotte Welinder

LAB HEAD: Victor Karlström

PROVIDER: PXD042819 | Pride | 2024-09-04

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	VK_ADAR3_co_IP_20230522_Mouse_Basic_Peptides.csv	Csv
	VK_ADAR3_co_IP_20230522_Mouse_Basic_Proteins.csv	Csv
	VK_ADAR3_co_IP_CtrlminusRNASe_1_CW_C2305_072.mzML	Mzml
	VK_ADAR3_co_IP_CtrlminusRNASe_1_CW_C2305_072.raw	Raw
	VK_ADAR3_co_IP_CtrlminusRNASe_2_CW_C2305_074.mzML	Mzml

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Publications

ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation.

Karlström Victor V Sagredo Eduardo A EA Planells Jordi J Welinder Charlotte C Jungfleisch Jennifer J Barrera-Conde Andrea A Engfors Linus L Daniel Chammiran C Gebauer Fátima F Visa Neus N Öhman Marie M

Nucleic acids research 20241001 19

ADAR3 is a catalytically inactive member of the family of adenosine deaminases acting on RNA (ADARs). Here we have investigated its function in the context of the developing mouse brain. The expression of ADAR3 gradually increases throughout embryogenesis and drops after birth. Using primary cortical neurons, we show that ADAR3 is only expressed in a subpopulation of in vitro differentiated neurons, which suggests specific functions rather than being a general regulator of ADAR editing in the br ...[more]

PMID: 39217468

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