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PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by pore-forming toxins

ABSTRACT: This research reveals that protein arginine methyltransferase-7 (PRMT-7) is indispensable to the nuclear transactivation of HLH-30. We demonstrated that PRMT-7 participates in the methylation of HLH-30 on its Rag complex binding domain to facilitate its nuclear localization. Moreover, we showed that PRMT7 is evolutionarily conserved to regulate TFEB cellular localization and repair plasma damage caused by PFTs in human intestinal cells.

INSTRUMENT(S): impact HD

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Hui-Chen Hsieh

LAB HEAD: Chang-Shi Chen

PROVIDER: PXD043101 | Pride | 2024-01-26

REPOSITORIES: Pride

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			Action	DRS
	HLH-30_R174_WT_Control_6378.mzML	Mzml
	HLH-30_R174_WT_Control_6378.rar	Other
	HLH-30_R174_WT_Cry5B_6747.mzML	Mzml
	HLH-30_R174_WT_Cry5B_6747.rar	Other
	HLH-30_R174_prmt-7_Control_6380.mzML	Mzml

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