Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Aina Maria Mas
LAB HEAD: Maite Huarte
PROVIDER: PXD043232 | Pride | 2023-10-24
REPOSITORIES: Pride
Action | DRS | |||
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83600_98293.pep.xml | Pepxml | |||
83601_98294.pep.xml | Pepxml | |||
83670_98293.pep.xml | Pepxml | |||
83671_98294.pep.xml | Pepxml | |||
84832_99400.pep.xml | Pepxml |
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Mas Aina Maria AM Goñi Enrique E Ruiz de Los Mozos Igor I Arcas Aida A Statello Luisa L González Jovanna J Blázquez Lorea L Lee Wei Ting Chelsea WTC Gupta Dipika D Sejas Álvaro Á Hoshina Shoko S Armaos Alexandros A Tartaglia Gian Gaetano GG Waga Shou S Ule Jernej J Rothenberg Eli E Gómez María M Huarte Maite M
Nature communications 20230724 1
Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains unclear. We show that the ORC1 subunit of the human Origin Recognition Complex interacts with RNAs transcribed from genes with origins in their transcription start sites (TSSs), displaying a positive correlation between RNA binding and origin activity. RNA dep ...[more]