Dataset Information

SWATH proteomics of NMN effects

ABSTRACT: Nicotinamide mononucleotide (NMN) has emerged as a promising therapeutic intervention for age-related disorders, including Type 2 Diabetes. In this study, we investigated the effects of NMN treatment on glucose uptake and its underlying mechanisms in mouse tissues (muscle, liver, brain and adipose tissue) and cell lines (HepG2 and C2C12). Through a comprehensive proteomic analysis, we uncovered a series of distinct organ-specific effects that contribute to the observed improvements in glucose metabolism.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Brain, Liver, Muscle, Adipose Tissue

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Roua Popescu

LAB HEAD: George Catalin Marinescu

PROVIDER: PXD043257 | Pride | 2024-06-16

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	C2C12_05FDR_0FC_HN_HH_Results2023-03-30.csv	Csv
	C2C12_05FDR_0FC_HN_HH_Results2023-03-30_long_gene_names.csv	Csv
	C2C12_report.unique_genes_matrix.tsv	Tabular
	C2C12_report_lib.tsv	Tabular
	C2C12_report_lib.tsv.speclib	Tabular

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Publications

Nicotinamide Mononucleotide (NMN) Works in Type 2 Diabetes through Unexpected Effects in Adipose Tissue, Not by Mitochondrial Biogenesis.

Popescu Roua Gabriela RG Dinischiotu Anca A Soare Teodoru T Vlase Ene E Marinescu George Cătălin GC

International journal of molecular sciences 20240223 5

Nicotinamide mononucleotide (NMN) has emerged as a promising therapeutic intervention for age-related disorders, including type 2 diabetes. In this study, we confirmed the previously observed effects of NMN treatment on glucose uptake and investigated its underlying mechanisms in various tissues and cell lines. Through the most comprehensive proteomic analysis to date, we discovered a series of novel organ-specific effects responsible for glucose uptake as measured by the IPGTT: adipose tissue g ...[more]

PMID: 38473844

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