Dataset Information
Neonatal and adult platelet proteomics
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Platelet
SUBMITTER: 
Hossein Fazelinia
LAB HEAD: Christopher S Thom MD, PhD
PROVIDER: PXD043330 | Pride | 2024-05-01
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20221027_104942_CT1703wp_dDIA.sne | Other | |||
| 20221101_105352_CT1703i_mergedSL.sne | Other | |||
| metadata_phos.csv | Csv | |||
| metadata_wholeproteome.csv | Csv | |||
| x221010_CT1703wp_DIA_01.raw | Raw |
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Publications
Quantitative label-free mass spectrometry reveals content and signaling differences between neonatal and adult platelets.
Journal of thrombosis and haemostasis : JTH 20231230 5
<h4>Background</h4>Recent clinical studies have shown that transfusions of adult platelets increase morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist stimulation, and emerging evidence suggests developmental differences in platelet immune functions.<h4>Objectives</h4>This study was designed to compare the proteome and phosphoproteome of resting adult and neonatal platelets.<h4>Methods</h4>We isolated resting umbilical cord blood-derived platelets from h ...[more]
