Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Dupuy Jean-William
LAB HEAD: Violaine Moreau
PROVIDER: PXD043640 | Pride | 2024-01-26
REPOSITORIES: Pride
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F013057.dat | Other | |||
F013058.dat | Other | |||
F013059.dat | Other | |||
F013060.dat | Other | |||
F013061.dat | Other |
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Cell death & disease 20240113 1
Entosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 (also known as RhoE) as an efficient inducer of this mechanism. We characterized the different stages and the molecular regulators of entosis induced after Rnd3 silencing. We demonstrated that this process depends on the RhoA/ROCK pathway, but not on E-cadherin. The proteomic profiling of entotic cells allowed us to id ...[more]