Proteomics

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Proteomic analysis of right-ventricular dysfunction (RVD) in patients with advanced chronic heart failure.

ABSTRACT: This research aimed to identify protein biomarkers of right ventricular dysfunction in patients with advanced heart failure with reduced ejection fraction (HFrEF). Samples of myocardium from both, right and left ventricles (RV, LV) were obtained from 10 HFrEF patients with right ventricular dysfunction (RVD), 10 HFrEF patients without RVD (noRVD) undergoing heart transplantation, and 10 non-failing unused donor hearts (Control). Tissue samples were homogenized and extracted using mild Triton X-100 detergent and processed by SP3 extraction to remove the detergent prior the analysis, (LFQ) proteomic analysis identified a total of 4 032 proteins in the left ventricle and 3 788 proteins in the right ventricle.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Cardiac Endothelial Cell, Neutrophil, Fibroblast, Cardiocyte

DISEASE(S): Heart Failure

SUBMITTER: Matěj Běhounek  

LAB HEAD: Doc. RNDr. Jiří Petrák, Ph.D.

PROVIDER: PXD043768 | Pride | 2025-02-11

REPOSITORIES: pride

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Publications

Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5.

Běhounek Matěj M   Lipcseyová Denisa D   Vít Ondřej O   Žáček Petr P   Talacko Pavel P   Husková Zuzana Z   Kikerlová Soňa S   Tykvartová Tereza T   Wohlfahrt Peter P   Melenovský Vojtěch V   Beneš Jan J   Petrák Jiří J  

Circulation. Heart failure 20250117

<h4>Background</h4>Right ventricular dysfunction (RVD) is common in patients with heart failure with reduced ejection fraction, and it is associated with poor prognosis. However, no biomarker reflecting RVD is available for routine clinical use.<h4>Methods</h4>Proteomic analysis of myocardium from the left ventricle and right ventricle (RV) of patients with heart failure with reduced ejection fraction with (n=10) and without RVD (n=10) who underwent heart transplantation was performed. Concentra  ...[more]

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