Proteomic analysis of global response to ionizing radiation in Hypsibius exemplaris
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ABSTRACT: Recent studies have shown that proteins unique to tardigrades are involved in the remarkable ability of these small animals to withstand desiccation and ionizing radiation (IR). For resistance to IR, only one tardigrade unique protein has been identified so far: Dsup, for DNA damage suppressor, found in R. varieornatus and H. exemplaris. Rv-Dsup protects from DNA damage by X-rays in human cells, suggesting that DNA protection is important for resistance to IR. Here, we chose to investigate the role of DNA repair and search for novel tardigrade unique genes involved in resistance to IR. For this, we performed an unbiased proteome analysis of H. exemplaris either untreated, or at 4h post-irradiation, 24h post-irradiation and after Bleomycin treatment.
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Hypsibius Exemplaris
SUBMITTER: Yohann Couté
LAB HEAD: Yohann Couté
PROVIDER: PXD043897 | Pride | 2024-06-17
REPOSITORIES: Pride
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