Ontology highlight
ABSTRACT:
INSTRUMENT(S): Bruker Daltonics timsTOF series
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Florian Fröhlich
LAB HEAD: Florian Fröhlich
PROVIDER: PXD044586 | Pride | 2023-10-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
CTRL1_2uL1h_681.d.zip | Other | |||
CTRL2_2uL1h_682.d.zip | Other | |||
CTRL3_2uL1h_683.d.zip | Other | |||
Sac1D573_1_2uL1h_685.d.zip | Other | |||
Sac1D573_2_2uL1h_686.d.zip | Other |
Items per page: 1 - 5 of 11 |
Nature communications 20231004 1
Sphingolipids are structural membrane components that also function in cellular stress responses. The serine palmitoyltransferase (SPT) catalyzes the rate-limiting step in sphingolipid biogenesis. Its activity is tightly regulated through multiple binding partners, including Tsc3, Orm proteins, ceramides, and the phosphatidylinositol-4-phosphate (PI4P) phosphatase Sac1. The structural organization and regulatory mechanisms of this complex are not yet understood. Here, we report the high-resoluti ...[more]