Ontology highlight
ABSTRACT:
INSTRUMENT(S): Bruker Daltonics timsTOF series
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) Saccharomyces Cerevisiae
SUBMITTER: Florian Fröhlich
LAB HEAD: Florian Fröhlich
PROVIDER: PXD048754 | Pride | 2024-09-12
REPOSITORIES: Pride
Körner Carolin C Schäfer Jan-Hannes JH Esch Bianca M BM Parey Kristian K Walter Stefan S Teis David D Januliene Dovile D Schmidt Oliver O Moeller Arne A Fröhlich Florian F
Cell reports 20240820 8
Sphingolipid levels are crucial determinants of neurodegenerative disorders and therefore require tight regulation. The Orm protein family and ceramides inhibit the rate-limiting step of sphingolipid biosynthesis-the condensation of L-serine and palmitoyl-coenzyme A (CoA). The yeast isoforms Orm1 and Orm2 form a complex with the serine palmitoyltransferase (SPT). While Orm1 and Orm2 have highly similar sequences, they are differentially regulated, though the mechanistic details remain elusive. H ...[more]