Ontology highlight
ABSTRACT:
INSTRUMENT(S): Bruker Daltonics timsTOF series
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) Saccharomyces Cerevisiae
SUBMITTER: Florian Fröhlich
LAB HEAD: Florian Fröhlich
PROVIDER: PXD048754 | Pride | 2024-09-12
REPOSITORIES: Pride
Action | DRS | |||
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CRTL_1_1295.d.zip | Other | |||
CRTL_2_1296.d.zip | Other | |||
CRTL_3_1297.d.zip | Other | |||
combined_zip.zip | Other | |||
lcb1DTM_1_1287.d.zip | Other |
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Cell reports 20240820 8
Sphingolipid levels are crucial determinants of neurodegenerative disorders and therefore require tight regulation. The Orm protein family and ceramides inhibit the rate-limiting step of sphingolipid biosynthesis-the condensation of L-serine and palmitoyl-coenzyme A (CoA). The yeast isoforms Orm1 and Orm2 form a complex with the serine palmitoyltransferase (SPT). While Orm1 and Orm2 have highly similar sequences, they are differentially regulated, though the mechanistic details remain elusive. H ...[more]