Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, timsTOF Pro, Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Brain Glioblastoma Multiforme
SUBMITTER: Emily Hsu
LAB HEAD: Peggy J. Farnham
PROVIDER: PXD044709 | Pride | 2024-08-09
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
HA_NTD_FO_control_rep1.raw | Raw | |||
HA_NTD_FO_control_rep2.raw | Raw | |||
HA_NTD_FO_control_rep3.raw | Raw | |||
HA_WT_ZFX.sne | Other | |||
HA_WT_ZFX_control_rep1.d.zip | Other |
Items per page: 1 - 5 of 25 |
Nucleic acids research 20240701 12
The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ∼200-250 bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction of ZFX increased Pol2 pausing at ZFX-regulated promoters. To further investigate the mechanisms by which ZFX regulates transcription, we determined regions of the protein needed for transactivation ...[more]