Proteomics

Dataset Information

0

Site-specifically acetylated G6PD


ABSTRACT: Site-specifically acetylated G6PD expressed in bacteria or cultured mammalian cells by genetically encoding the incorporation of acetylated lysine. Purified G6PD (expressed in E. coli) or immunopurified G6PD (expressed in HEK293T cells) were subjected to LC-MS/MS analysis.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Eyal Arbely  

LAB HEAD: Eyal Arbely

PROVIDER: PXD044906 | Pride | 2023-10-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
AcK386.RAW Raw
AcK386.msf Msf
AcK386.pep.xml Pepxml
AcK386_minus.RAW Raw
AcK386_minus.msf Msf
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Publications

Acetylation-dependent coupling between G6PD activity and apoptotic signaling.

Wu Fang F   Muskat Natali H NH   Dvilansky Inbar I   Koren Omri O   Shahar Anat A   Gazit Roi R   Elia Natalie N   Arbely Eyal E  

Nature communications 20231005 1


Lysine acetylation has been discovered in thousands of non-histone human proteins, including most metabolic enzymes. Deciphering the functions of acetylation is key to understanding how metabolic cues mediate metabolic enzyme regulation and cellular signaling. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is acetylated on multiple lysine residues. Using site-specifically acetylated G6PD, we show that acetylation can activate (AcK89) and inhi  ...[more]

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