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Proteomics Analysis Reveals differences in Differencial Expressed Proteins Between Cardiopathic LMNA utations

ABSTRACT: Quantitative proteomics of HEK293 cell expressing LMNA mutations

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Early Embryonic Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: kyle brown

LAB HEAD: Lee Eckhardt

PROVIDER: PXD045092 | Pride | 2024-08-09

REPOSITORIES: Pride

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			Action	DRS
	E317K2_analysis.tdf_bin	Other
	E317K3_analysis.tdf_bin	Other
	E317K4_analysis.tdf_bin	Other
	E317K_1_analysis.tdf_bin	Other
	N195K1analysis.tdf_bin	Other

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1 - 5 of 31

Publications

Global Proteomic Analysis Reveals Alterations in Differentially Expressed Proteins between Cardiopathic Lamin A/C Mutations.

Anderson Corey L CL Brown Kyle A KA North Ryan J RJ Walters Janay K JK Kaska Sara T ST Wolff Mathew R MR Kamp Timothy J TJ Ge Ying Y Eckhardt Lee L LL

Journal of proteome research 20240508 6

Lamin A/C (LMNA) is an important component of nuclear lamina. Mutations cause arrhythmia, heart failure, and sudden cardiac death. While LMNA-associated cardiomyopathy typically has an aggressive course that responds poorly to conventional heart failure therapies, there is variability in severity and age of penetrance between and even within specific mutations, which is poorly understood at the cellular level. Further, this heterogeneity has not previously been captured to mimic the heterozygous ...[more]

PMID: 38718259

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Secretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins

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mini-Complexome Profiling, an FDR-controlled workflow for global targeted Detection of protein complexes (Hek293 data)

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