Comparaison of APOE4 and APOE3 transcriptomic profiles from derived cell lines in absence or presence of an inflammatory stimulus
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ABSTRACT: Our objective was to study some of the molecular changes that associate with APOE4, ultimately aiming at identifying new mechanisms that support exacerbated neuroinflammation as a cause of functional deterioration in Alzheimer's disease (AD). We hypothesize that the increased risk of developing AD in APOE4 carriers could be the consequence of altered inflammatory regulatory functions in astrocytes, which would be key effectors of the pathological process.
ORGANISM(S): Homo sapiens
SUBMITTER: Philippe Benech
PROVIDER: E-MTAB-9625 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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