Dataset Information

Glycosylation of somatic extracts and secretome in the infective stage of the helminth Fasciola hepatica

ABSTRACT: Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excretedsecreted (ES) products and surface/somatic molecules to interact with host cells and tissues and to evade the host's immune responses. Here, we employed glycoproteomic and proteomic analyses to determine the glycosylation profile of proteins within the NEJs’ somatic (Som) and ES extracts.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Fasciola Hepatica (liver Fluke)

SUBMITTER: Jonas Nilsson

LAB HEAD: John Dalton

PROVIDER: PXD045488 | Pride | 2024-01-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Byonic_N_glycopeptides_PNGF_samples.xlsx	Xlsx
	Byonic_PSMs_N_glycopeptides.xlsx	Xlsx
	Byonic_PSMs_O_glycopeptides.xlsx	Xlsx
	File_list.xlsx	Xlsx
	N_glycan_compositions.txt	Txt

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Publications

Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica.

De Marco Verissimo Carolina C Cwiklinski Krystyna K Nilsson Jonas J Mirgorodskaya Ekaterina E Jin Chunsheng C Karlsson Niclas G NG Dalton John P JP

Molecular & cellular proteomics : MCP 20231121 12

Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excreted-secreted (ES) products and surface/somatic molecules to interact with host cells and tissues and to evade the host's immune responses, such as disarming complement and shedding bound antibody. While -omics technologies have generated extensive databases of NEJs' proteins and their expression, detailed knowledge of t ...[more]

PMID: 37993102

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