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Exploring the female genital tract mycobiome in young South African women using metaproteomics

ABSTRACT: Female genital tract (FGT) diseases such as bacterial vaginosis (BV) and sexually transmitted infections are prevalent in South Africa, with young women being at an increased risk. Since imbalances in the FGT microbiome are associated with FGT diseases, it is vital to investigate the factors that influence FGT health. The mycobiome plays an important role in regulating mucosal health, especially when the bacterial component is disturbed. However, we have a limited understanding of the FGT mycobiome since many studies have focused on bacterial communities and have neglected low abundance taxonomic groups, such as fungi. To reduce this knowledge deficit, we present the first large-scale metaproteomic study to define the taxonomic composition and potential functional processes of the FGT mycobiome in South African reproductive-age women. We examined FGT fungal communities present in 123 women by collecting lateral vaginal wall swabs for liquid chromatography-tandem mass spectrometry.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Trichomonas Vaginalis Homo Sapiens (human) Chlamydia Trachomatis Neisseria Gonorrhoeae

TISSUE(S): Vaginal Epithelium, Epithelial Cell

DISEASE(S): Bacterial Vaginosis

SUBMITTER: Tamlyn Kirstey Gangiah

LAB HEAD: Lindi Masson

PROVIDER: PXD046053 | Pride | 2025-03-28

REPOSITORIES: Pride

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			Action	DRS
	0843_100_30v2.raw	Raw
	0843_101_30v3_rpt.raw	Raw
	0843_102_107v2.raw	Raw
	0843_103_71v2.raw	Raw
	0843_104_152v3_rpt.raw	Raw

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