Proteomics

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Global, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice


ABSTRACT: The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic ?-cells12. Yet, the relevance of ?-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demonstrated for normoglycemic and insulin sensitive lean mice, questioning whether inceptor regulation of INS1R/IGF1R action also plays a role in glucose metabolism under conditions of diet-induced obesity and insulin resistance. Here we demonstrate that whole-body germline loss of inceptor improves glucose metabolism in diet-induced obese mice with only minimal effects on weight and body composition. To assess the effect in different tissues we performed proteomics in the global, neuronal and beta cell specific mouse knock-outs.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Quadriceps, Brain, Liver

DISEASE(S): Obesity

SUBMITTER: Natalie Krahmer  

LAB HEAD: Natalie Krahmer

PROVIDER: PXD046256 | Pride | 2024-01-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20230802_SRDB_Gerald_HypKO_13.raw Raw
20230802_SRDB_Gerald_HypKO_48.raw Raw
20230802_SRDB_Gerald_HypKO_82.raw Raw
20230802_SRDB_Gerald_HypWT_18.raw Raw
20230802_SRDB_Gerald_HypWT_53.raw Raw
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