Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Escherichia Coli
SUBMITTER: Kish Adoni
LAB HEAD: Konstantinos Thalassinos
PROVIDER: PXD046392 | Pride | 2024-05-24
REPOSITORIES: Pride
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111023_QBP_BS3_1ug_bio1tec1.raw | Raw | |||
111023_QBP_BS3_1ug_bio1tec2.raw | Raw | |||
111023_QBP_BS3_1ug_bio1tec3.raw | Raw | |||
111023_QBP_BS3_1ug_bio2tec1.raw | Raw | |||
111023_QBP_BS3_1ug_bio2tec2.raw | Raw |
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Molecular & cellular proteomics : MCP 20240122 3
We propose a pipeline that combines AlphaFold2 (AF2) and crosslinking mass spectrometry (XL-MS) to model the structure of proteins with multiple conformations. The pipeline consists of two main steps: ensemble generation using AF2 and conformer selection using XL-MS data. For conformer selection, we developed two scores-the monolink probability score (MP) and the crosslink probability score (XLP)-both of which are based on residue depth from the protein surface. We benchmarked MP and XLP on a la ...[more]