Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ao Liu
LAB HEAD: Henry N. Higgs
PROVIDER: PXD046824 | Pride | 2024-06-16
REPOSITORIES: pride
Items per page: 5 1 - 5 of 27 |
Liu Ao A Hatch Anna L AL Higgs Henry N HN
Molecular biology of the cell 20231129 2
Drp1 is a dynamin family GTPase required for mitochondrial and peroxisomal division. Oligomerization increases Drp1 GTPase activity through interactions between neighboring GTPase domains. In cells, Drp1 is regulated by several factors including Drp1 receptors, actin filaments, cardiolipin, and phosphorylation at two sites: S579 and S600. Commonly, phosphorylation of S579 is considered activating, while S600 phosphorylation is considered inhibiting. However, direct effects of phosphorylation on ...[more]