Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Affymetrix GeneChip Mouse Gene 1.0 arrays of RNA extracted from gastrocnemius muscle of 4 global Ppp3cb KO mice and 4 corresponding WT littermates, and 4 skeletal muscle-specific Ppp3r1Mlc1fCre KO and 4 corresponding WT littermates.


ABSTRACT: Global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle but not adipose tissue or liver led to protection from high-fat diet induced obesity and comorbid sequelæ. Ser637 hyperphosphorylation of dynamin-related protein 1 (Drp1) in skeletal muscle of calcineurin-deficient mice was associated with mitochondrial elongation into power-cable shaped filaments, increased mitochondrial respiration, but attenuated exercise performance. Mice used for microarray analyses were all male, and chronically exposed to HFD for at least 8 weeks.

ORGANISM(S): Mus musculus

SUBMITTER: Bruce Aronow 

PROVIDER: E-GEOD-71174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-07-22 | GSE71174 | GEO
2023-10-05 | E-MTAB-13355 | biostudies-arrayexpress
2013-08-13 | E-GEOD-49797 | biostudies-arrayexpress
2013-03-22 | E-GEOD-31947 | biostudies-arrayexpress
2022-04-04 | GSE149010 | GEO
2018-12-12 | E-MTAB-6726 | biostudies-arrayexpress
2015-07-01 | E-GEOD-63198 | biostudies-arrayexpress
2022-04-04 | PXD018885 | Pride
2022-02-17 | PXD029963 | Pride
2022-05-19 | PXD028157 | Pride