Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 240
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Frederic Lamoliatte
LAB HEAD: Yogesh Kulathu
PROVIDER: PXD046991 | Pride | 2024-03-22
REPOSITORIES: Pride
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Makhlouf Linda L Peter Joshua J JJ Magnussen Helge M HM Thakur Rohan R Millrine David D Minshull Thomas C TC Harrison Grace G Varghese Joby J Lamoliatte Frederic F Foglizzo Martina M Macartney Thomas T Calabrese Antonio N AN Zeqiraj Elton E Kulathu Yogesh Y
Nature 20240221 8003
Stalled ribosomes at the endoplasmic reticulum (ER) are covalently modified with the ubiquitin-like protein UFM1 on the 60S ribosomal subunit protein RPL26 (also known as uL24)<sup>1,2</sup>. This modification, which is known as UFMylation, is orchestrated by the UFM1 ribosome E3 ligase (UREL) complex, comprising UFL1, UFBP1 and CDK5RAP3 (ref. <sup>3</sup>). However, the catalytic mechanism of UREL and the functional consequences of UFMylation are unclear. Here we present cryo-electron microscop ...[more]