Proteomics

Dataset Information

0

Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a new therapeutic target


ABSTRACT: Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioural alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal growth hormone in utero, and low IGF-1 serum levels correlate with preterm poor neurodevelopmental outcomes. Here, we mimicked IGF-1 deficiency of preterm newborns in mice by perinatal administration of an IGF-1 receptor antagonist. This resulted in sex-biased brain microstructural, functional, and behavioural alterations, resembling those of ex-preterm children, which we characterized performing parallel mouse/human behavioural tests. Pharmacological enhancement of GABAergic tonic-inhibition by the FDA-approved drug ganaxolone rescued functional/behavioural alterations in mice. Establishing an unprecedented mouse model of prematurity, our work dissects the mechanisms at the core of abnormal behaviours and identifies a new, readily-translatable therapeutic strategy for preterm brain disorders.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Martina Bartolucci  

LAB HEAD: Andrea Petretto

PROVIDER: PXD047222 | Pride | 2024-06-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20231124_151752_Phospho_Hippo.sne Other
CTRL2_HIPPO_2.raw Raw
CTRL3_HIPPO_3.raw Raw
CTRL4_HIPPO_4.raw Raw
CTRL5_HIPPO_5.raw Raw
Items per page:
1 - 5 of 39
altmetric image

Publications


Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioral alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal growth hormone in utero, and low IGF-1 serum levels correlate with preterm poor neurodevelopmental outcomes. Here, we mimicked IGF-1 deficiency of preterm newborns in mice by perinatal administration of an IGF-1 receptor antagonist. This resulted in sex-biased brain microstructural, functional, and behav  ...[more]

Similar Datasets

2024-06-16 | PXD047704 | Pride
2024-10-02 | PXD053482 | Pride
2009-02-06 | E-GEOD-14722 | biostudies-arrayexpress
2023-02-21 | PXD028965 | Pride
2019-09-26 | PXD013644 | Pride
2024-07-19 | PXD047516 | Pride
2021-11-18 | PXD023690 | Pride
2013-11-21 | E-GEOD-52572 | biostudies-arrayexpress
2017-05-04 | E-GEOD-71123 | biostudies-arrayexpress
2023-03-11 | PXD037722 | Pride