Dataset Information

DIA proteomics in neck gland tissue of male Bactrian camel

ABSTRACT: The neck gland, an exclusive gland found in male camels, has been proven to secrete an amber-colored fluid and volatile substances during the mating season, exhibiting the capability to induce estrus in female camels. In this study, data-independent acquisition (DIA) proteomics was utilized to analyze differentially expressed proteins (DEPs) in the neck gland tissue of male Bactrian camels

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Camelus Bactrianus

TISSUE(S): Neck

SUBMITTER: MNEG QUANLU

LAB HEAD: Meng Quan LU

PROVIDER: PXD047457 | Pride | 2024-08-10

REPOSITORIES: Pride

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Publications

Exploring the Mechanism of H2S Synthesis in Male Bactrian Camel Poll Glands Based on Data Independent Acquisition Proteomics and Non-Targeted Metabolomics.

Yuan Bao B Zhang Quanwei Q Zhang Bohao B Li Jianfu J Chen Wenli W Zhao Yu Y Dong Weitao W Zhang Yong Y Zhao Xingxu X Gao Yuan Y

International journal of molecular sciences 20240713 14

During estrus, the poll glands of male Bactrian Camels (Camelus Bactrianus) become slightly raised, exuding a large amount of pale yellow watery secretion with a characteristic odor that may contain hydrogen sulfide (H2S). However, whether H2S can be synthesized in the poll glands of male Bactrian Camels and its role in inducing camel estrus remains unclear. This study aimed to identify differentially expressed proteins (DEPs) and signaling pathways in the poll gland ...[more]

PMID: 39062942

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Project description:Clinical studies have revealed that social support improves the outcome of cancer patients while epidemiological studies suggest that social isolation increases the risk of death associated with several chronic diseases. However, the precise biological consequences of an unfavorable social environment have not been defined. To do so, robust, reproducible pre-clinical models are needed to study the mechanisms whereby an adverse environment impacts on gene expression and cancer biology. Because random assignment of inbred laboratory mice to well-defined social environments allows accurate and repeated measurements of behavioral and endocrine parameters, transgenic mice provide a pre-clinical framework with which to begin to determine gene-environment mechanisms. In this study, we found that female C3(1)/SV40 T-antigen mice deprived of social interaction from weaning exhibited increased expression of genes encoding key metabolic pathway enzymes in the pre-malignant mammary gland. Chronic social isolation was associated with upregulated fatty acid synthesis and glycolytic pathway gene expression - both pathways known to contribute to increased breast cancer growth. Consistent with the expression of metabolic genes, isolated mice subsequently developed significantly larger mammary gland tumors compared to group-housed mice. Endocrine evaluation confirmed that isolated mice developed a heightened corticosterone stress response compared to group-housed mice. Together, these transdisciplinary studies show for the first time that an adverse social environment is associated with altered mammary gland gene expression and tumor growth. Moreover, the identification of specific alterations in metabolic pathways favoring tumor growth suggests potential molecular biomarkers and/or targets (e.g. fatty acid synthesis) for preventive intervention in breast cancer. Experiment Overall Design: SV40 Tag mice we isolated or grouped at weaning. Mouse mammary glands were rapidly excised at necropsy and immediatley flash frozen to detect difference in gene expression between thoraci MG from isolated versus group-housed female mice.

Dataset Information

DIA proteomics in neck gland tissue of male Bactrian camel

Publications

Exploring the Mechanism of H<sub>2</sub>S Synthesis in Male Bactrian Camel Poll Glands Based on Data Independent Acquisition Proteomics and Non-Targeted Metabolomics.

Similar Datasets

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