Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuron, Cell Culture
DISEASE(S): Parkinson's Disease
SUBMITTER: Hossein Fazelinia
LAB HEAD: Ophir Shalem, Ph.D.
PROVIDER: PXD048283 | Pride | 2024-05-22
REPOSITORIES: Pride
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20220708_104910_OS1678_dDIA.sne | Other | |||
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x220701_OS1678_01.raw | Raw | |||
x220701_OS1678_02.raw | Raw | |||
x220701_OS1678_03.raw | Raw |
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Santhosh Kumar Saranya S Naseri Nima N NN Pather Sarshan R SR Hallacli Erinc E Ndayisaba Alain A Buenaventura Chris C Acosta Karen K Roof Jennifer J Fazelinia Hossein H Spruce Lynn A LA Luk Kelvin K Khurana Vikram V Rhoades Elizabeth E Shalem Ophir O
Science advances 20240209 6
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's disease and related neurodegenerative diseases. Lowering αSyn is being actively investigated as a therapeutic modality. Here, we systematically map the regulatory network that controls endogenous αSyn using sequential CRISPR-knockout and -interference screens in an αSyn gene (<i>SNCA</i>)-tagged cell line and induced pluripotent stem cell-derived neurons (iNeurons). We uncover αSyn modifiers at multiple reg ...[more]