Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Type B Pancreatic Cell
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Alex Montoya
LAB HEAD: Dr Pavel Shliaha
PROVIDER: PXD048465 | Pride | 2024-03-22
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Mmusculus_UP000000589_10090_20220322.fasta | Fasta | |||
Rnorvegicus_UP000002494_10116_20220531.fasta | Fasta | |||
Swissprot_human_20180104.fasta | Fasta | |||
b010p040_M1_TR01.raw | Raw | |||
b010p040_M1_TR02.raw | Raw |
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Yu Vanessa V Yong Fiona F Marta Angellica A Khadayate Sanjay S Osakwe Adrien A Bhattacharya Supriyo S Varghese Sneha S SS Chabosseau Pauline P Tabibi Sayed M SM Chen Keran K Georgiadou Eleni E Parveen Nazia N Suleiman Mara M Stamoulis Zoe Z Marselli Lorella L De Luca Carmela C Tesi Marta M Ostinelli Giada G Delgadillo-Silva Luis L Wu Xiwei X Hatanaka Yuki Y Montoya Alex A Elliott James J Patel Bhavik B Demchenko Nikita N Whilding Chad C Hajkova Petra P Shliaha Pavel P Kramer Holger H Ali Yusuf Y Marchetti Piero P Sladek Robert R Dhawan Sangeeta S Withers Dominic J DJ Rutter Guy A GA Millership Steven J SJ
bioRxiv : the preprint server for biology 20231130
<h4>Aims/hypothesis</h4>Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly-connected 'hub' cells, important for the propagation of intercellular Ca<sup>2+</sup> waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes. At present, the ...[more]