Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
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ABSTRACT: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly-connected ‘hub’ cells, important for the propagation of intercellular Ca2+ waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes. At present, the molecular mechanisms through which beta cell hierarchy is established are poorly understood. Changes at the level of the epigenome provide one such possibility which we explore here by focussing on the imprinted gene neuronatin(Nnat), which is required for normal insulin synthesis and secretion.
INSTRUMENT(S): Q Exactive HF-X, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Type B Pancreatic Cell
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Alex Montoya
LAB HEAD: Dr Pavel Shliaha
PROVIDER: PXD048465 | Pride | 2024-03-22
REPOSITORIES: pride
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