Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain, Stem Cell
SUBMITTER: Haiyan Tan
LAB HEAD: Junmin Peng
PROVIDER: PXD048730 | Pride | 2024-06-22
REPOSITORIES: Pride
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Zhou Xiaoting X Lee You-Kyung YK Li Xianting X Kim Henry H Sanchez-Priego Carlos C Han Xian X Tan Haiyan H Zhou Suiping S Fu Yingxue Y Purtell Kerry K Wang Qian Q Holstein Gay R GR Tang Beisha B Peng Junmin J Yang Nan N Yue Zhenyu Z
Nature communications 20240410 1
Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human neurons remain elusive. Here we report a systematic investigation of neuronal autophagy targets through integrated proteomics. Deep proteomic profiling of multiple autophagy-deficient lines of human induced neurons, mouse brains, and brain LC3-interactome reve ...[more]