Dataset Information

Quantification of proteins in the endothelial cell-pericyte interface with and without treatment with 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP)

ABSTRACT: Goal of the study was to identify (using proteomics) the consequences of the lipocine 19,20-DHDP on the proteins enriched in the junctions between endothelial cells and pericytes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ilka Wittig

LAB HEAD: Ingrid Fleming

PROVIDER: PXD049131 | Pride | 2025-01-07

REPOSITORIES: pride

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Dataset's files

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			Action	DRS
	P19_047_Sebastian_SK014_F_CTL1_B.raw	Raw
	P19_047_Sebastian_SK014_F_CTL1_SCX1.raw	Raw
	P19_047_Sebastian_SK014_F_CTL1_SCX2.raw	Raw
	P19_047_Sebastian_SK014_F_CTL1_SCX3.raw	Raw
	P19_047_Sebastian_SK014_F_CTL1_SCX4.raw	Raw

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Publications

Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid.

Kempf Sebastian S Popp Rüdiger R Naeem Zumer Z Frömel Timo T Wittig Ilka I Klatt Stephan S Fleming Ingrid I

Cells 20240826 17

The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms regulating pericyte-endothelial cell communication remain unclear. This study investigated the formation and function of pericyte tunneling nanotubes (TNTs) and their impact on endothelial cell metabolism. TNTs were analyzed in vitro in retinas and co-cultures of pericytes and endothelial cells. Using mass spectrometry, the influence of pericytes on endothelial cell metabolism was examined. TNTs were prese ...[more]

PMID: 39273001

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