Proteomics

Dataset Information

0

Proteome characterisation of SARS-CoV-2 virions derived from different cells/species

ABSTRACT: The virions of all enveloped viruses, including SARS-CoV-2 are composed of not only known structural viral proteins (S, N, M, E) but also include some SARS-CoV-2 non-structural proteins as well as host cell protein that were accidentally packed into virions. The project aims to identify these proteins and further study their role in virus life cycle.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Cercopithecus Aethiops (green Monkey) (grivet) Homo Sapiens (human)

TISSUE(S): Blood Cell

SUBMITTER: Nara Marella  

LAB HEAD: Anna Repic

PROVIDER: PXD050009 | Pride | 2024-11-04

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
ECAR131-P12723-M1088-A01-Caco-Experiment-August2022-1.pdResult Other
ECAR131-P12723-M1088-A01-Caco-Experiment-August2022-1_Peptide_Groups.xlsx Xlsx
ECAR131-P12723-M1088-A01-Caco-Experiment-August2022-1_Proteins.xlsx Xlsx
ECAR131-P12723-M1088-A01-Caco-mock-1-1.raw Raw
ECAR131-P12723-M1088-A01-Caco-mock-1-August2022.msf Msf
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Publications

SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis.

Gebetsberger Laura L   Malekshahi Zahra Z   Teutsch Aron A   Tajti Gabor G   Fontaine Frédéric F   Marella Nara N   Mueller André A   Prantl Lena L   Stockinger Hannes H   Stoiber Heribert H   Ohradanova-Repic Anna A  

Emerging microbes & infections 20241028 1

The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tightly modulated by a set of membrane-associated and fluid-phase regulators of complement activation (RCAs). Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks host cellular RCA members CD55 and CD59 and serum-derived Factor H (FH) to resist antibody-dependent co  ...[more]

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