Unknown,Transcriptomics,Genomics,Proteomics

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A3G and A3F CLIP


ABSTRACT: APOBEC3G and APOBEC3F are cell-encoded restriction factors that have evolved to counteract virus infections. When packaged into HIV-1 particles, A3G and A3F impair reverse transcription and induce the hypermutation of viral DNA. We employed a next generation sequencing approach to identify the RNAs that these proteins bind in HIV-1 infected cells and HIV-1 virions. We then analysed the mechanism of packaging of APOBEC3 in detail.

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Homo sapiens

SUBMITTER: Luis Apolonia 

PROVIDER: E-MTAB-2700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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