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Epi-proteomic assessment of backpain therapy

ABSTRACT: This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices. We report that the therapy improves agility, attenuates backpain, and also triggers healthier habits. We find that a subset of participants´ histone methylation and acetylation profiles cluster samples according to their therapy status, before or after therapy. Integrating epigenetic reprogramming of both buccal cells and PBMCs reveals that these concomitant changes are concordant with higher levels of self-rated backpain improvement and agility gain. Additionally, epigenetic changes correlate with changes in immune-response plasma factors, reflecting their comparable ability to rate therapy effects at the molecular level. Additionally, we performed an exploratory analysis to confirm the usability of molecular profiles in 1) mapping lifestyle choices, and 2) evaluating the distance of a given participant to an optimal health state.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Oral Mucosa, Leukocyte, Epithelial Cell, Keratinocyte

DISEASE(S): Limb Muscle

SUBMITTER: Moritz Voelker-Albert

LAB HEAD: Dr. Moritz Voelker-Albert

PROVIDER: PXD050113 | Pride | 2024-10-21

REPOSITORIES: Pride

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			Action	DRS
	FPZ_220105_SdS_InGelDig_AT_05_PBMC.raw	Raw
	FPZ_220105_SdS_InGelDig_AT_05_SWAB.raw	Raw
	FPZ_220105_SdS_InGelDig_AT_06_PBMC.raw	Raw
	FPZ_220105_SdS_InGelDig_AT_06_SWAB.raw	Raw
	FPZ_220105_SdS_InGelDig_AT_08_PBMC.raw	Raw

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