Proteomics

Dataset Information

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Studying the role of LMTK3 in the brain


ABSTRACT: Studying the phosphorylation events related to LMTK3 and its associated proteins in the brain. LMTK3 appears to be associated with the excitatory and inhibitory synaptic machinery, therefore this study was carried out to examine it's role in modulating inhibitory synapses.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Brain, Forebrain, Cell Culture

SUBMITTER: Joshua Smalley  

LAB HEAD: Joshua Smalley

PROVIDER: PXD050212 | Pride | 2024-05-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
77700.mzXML Mzxml
77700.mzid.gz Mzid
77700.raw Raw
77700p.mzid.gz Mzid
78277.mzXML Mzxml
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Publications

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl<sup>-</sup> extrusion.

Cho Noell N   Kontou Georgina G   Smalley Joshua L JL   Bope Christopher C   Dengler Jacob J   Montrose Kristopher K   Deeb Tarek Z TZ   Brandon Nicholas J NJ   Yamamoto Tadashi T   Davies Paul A PA   Giamas Georgios G   Moss Stephen J SJ  

iScience 20240315 4


LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is unknown. Here, we demonstrate that LMTK3 copurifies and binds to KCC2, a neuron-specific K<sup>+</sup>/Cl<sup>-</sup> transporter. KCC2 activity is essential for Cl<sup>-</sup>-mediated hyperpolarizing GABA<sub>A</sub>R receptor currents, the unitary events th  ...[more]

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