Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain, Forebrain, Cell Culture
SUBMITTER: Joshua Smalley
LAB HEAD: Joshua Smalley
PROVIDER: PXD050212 | Pride | 2024-05-22
REPOSITORIES: Pride
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Cho Noell N Kontou Georgina G Smalley Joshua L JL Bope Christopher C Dengler Jacob J Montrose Kristopher K Deeb Tarek Z TZ Brandon Nicholas J NJ Yamamoto Tadashi T Davies Paul A PA Giamas Georgios G Moss Stephen J SJ
iScience 20240315 4
LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is unknown. Here, we demonstrate that LMTK3 copurifies and binds to KCC2, a neuron-specific K<sup>+</sup>/Cl<sup>-</sup> transporter. KCC2 activity is essential for Cl<sup>-</sup>-mediated hyperpolarizing GABA<sub>A</sub>R receptor currents, the unitary events th ...[more]