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Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies

ABSTRACT: The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. Here, the efficacy of pyridostigmine (PYR) and trandolapril (TRA) as antihypertensive and antihypertrophic agents was investigated and compared in hypertensive SHR and normotensive WKY rats. In parallel, we investigated the effects of these drugs on myocardial β-adrenergic and cholinergic signaling pathways and protein expression profiles.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

SUBMITTER: Pavel Talacko

LAB HEAD: Jiri Novotny

PROVIDER: PXD050397 | Pride | 2024-09-10

REPOSITORIES: Pride

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			Action	DRS
	1172-SC1_20220922170705.raw	Raw
	1172-SC2_20220922192940.raw	Raw
	1172-SC3_20220922215214.raw	Raw
	1172-SP1_20220923004627.raw	Raw
	1172-SP2_20220923030859.raw	Raw

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Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies

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