Dataset Information

Identification of differentially expressed proteins in lung cancer H157 cells after nanocomposite AANL-SeNPs treatment with DIA-MS detection

ABSTRACT: H157 cells were treated with nanocomposite AANL-SeNPs and harvested for mass spectrometry detection. The mass spectrum data were obtained by timsTOF Pro combined with UltiMate 3000 RSLCnano liquid chromatograph system. DIA-NN software is used to analyze DIA original data files. The differentially expressed proteins were screened by quantitative proteomics.

INSTRUMENT(S): autoflex

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Wounds And Injuries

SUBMITTER: Yanxia Jin

LAB HEAD: Yanxia Jin

PROVIDER: PXD044000 | Pride | 2024-05-22

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	23020606_JYX_AANL-1_BA4_1_8106.d.rar	Other
	23020606_JYX_AANL-2_BA5_1_8108.d.rar	Other
	23020606_JYX_Control-1_BA2_1_8102.d.rar	Other
	23020606_JYX_Control-2_BA3_1_8104.d.rar	Other
	checksum.txt	Txt

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Publications

A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer.

Zhang Yueyang Y Chen Ying Y Wang Bo B Cai Ying Y Zhang Menghang M Guo Xin X Wu Aobo A Wang Weidong W Liu Na N Wang Xianping X Gong Yongsheng Y Pan Jicheng J Jin Yanxia Y

Bioorganic chemistry 20240515

Lung cancer is a malignant tumor with high mortality and drug resistance. Therefore, it is urgent to explore natural and nontoxic drugs to treat lung cancer. In this study, the natural active ingredient AANL extracted from Agrocybe aegirita was used to modify nanoselenium by an oxidation-reduction method. Transmission electron microscope detection and infrared spectroscopy showed that a novel selenium nanocomposite named AANL-SeNPs was successfully prepared. The results of nanoscale characteriza ...[more]

PMID: 38761707

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