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Oxidative stress initiates hemodynamic change in CKD induced heart disease

ABSTRACT: Cardiovascular disease is highly prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of CKD-related deaths. The mechanisms underlying the detrimental impact of CKD on the heart are still incompletely understood, but CKD is associated with endocrinal, inflammatory and hemodynamic changes that impact the heart and may contribute to the development of uremic cardiomyopathy.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

SUBMITTER: Jan Bernd Stöckl

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD050994 | Pride | 2025-01-17

REPOSITORIES: pride

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Oxidative stress initiates hemodynamic change in CKD-induced heart disease.

Sen Payel P Hamers Jules J Sittig Theresa T Shashikadze Bachuki B d'Ambrosio Laura L Stöckl Jan B JB Bierschenk Susanne S Zhang Hengliang H d'Alessio Chiara C Zandbergen Lotte M LM Pauly Valerie V Clauss Sebastian S Wolf Eckhard E Dendorfer Andreas A Fröhlich Thomas T Merkus Daphne D

Basic research in cardiology 20241015 6

Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine identified changes in microvascular structure and function, as well as changes in mitochondrial structure and oxidative stress. However, CKD was combined with metabolic derangement, thereby obscuring the contribution of CKD alone. Therefore, we studied the impact of CKD on the heart and combined proteome studies with measurement of cardiac function and perfusion to identify pro ...[more]

PMID: 39404904

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