Proteomics

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Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.

ABSTRACT: A proteomic and peptidomics analysis of serum from patients suffering from metabolic dysfunction-associated steatotic liver disease. Proteomics was performed initially on a set of patients with varying degrees of liver disease. Following close analysis of the results, a peptidomics based analysis was performed and identified significant numbers of degraded and oxidised peptides from apolipoproteins. A more targeted peptidomics analysis was performed on a larger cohort and the oxidation status of small apolipoproteins demonstrated a high accuracy of precision for liver disease diagnosis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Richard Kay  

LAB HEAD: Fiona Gribble

PROVIDER: PXD052061 | Pride | 2025-01-21

REPOSITORIES: pride

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Publications

Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease.

Mocciaro Gabriele G   George Amy L AL   Allison Michael M   Frontini Mattia M   Huang-Doran Isabel I   Reiman Frank F   Gribble Fiona F   Griffin Julian L JL   Vidal-Puig Antonio A   Azzu Vian V   Kay Richard R   Vacca Michele M  

Liver international : official journal of the International Association for the Study of the Liver 20250201 2

<h4>Background</h4>Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) encompasses a spectrum of histological conditions ranging from simple steatosis to fibrosing steatohepatitis, and is a risk factor for cardiovascular diseases (CVD). While oxidised apolipoproteins A and B have been linked to obesity and CVD, the association between other oxidised apolipoproteins and MASLD is yet to be established. To fill this gap, we characterised the circulating serum peptidome of patients with  ...[more]

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