Dataset Information

Characterization of the choroid plexus role in Alzheimer’s disease pathophysiology

ABSTRACT: Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer’s disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely unknown. We aim to unravel the relation between ChP functioning and core AD pathogenesis using a unique proteomic approach in mice and humans. We used an APP knock-in mouse model, APPNL-G-F, exhibiting amyloid pathology, to study the association between AD brain pathology and protein changes in mouse ChP tissue and CSF using liquid chromatography mass spectrometry. Mouse proteomes were investigated at the age of 7 weeks (n=5) and 40 weeks (n=5). Results were compared with existing human AD CSF proteomic data (n=496) to identify key proteins and pathways associated with ChP changes in AD.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Cerebrospinal Fluid

SUBMITTER: Sara Dufour

LAB HEAD: Aurore Delvenne

PROVIDER: PXD052590 | Pride | 2024-08-10

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	H093027_1p_Ionopticks6_PM4_PRC-5795_Vdbroucke_9.raw	Raw
	H093029_1p_Ionopticks6_PM4_PRC-5795_Vdbroucke_25.raw	Raw
	H093031_1p_Ionopticks6_PM4_PRC-5795_Vdbroucke_23.raw	Raw
	H093033_1p_Ionopticks6_PM4_PRC-5795_Vdbroucke_17.raw	Raw
	H093035_1p_Ionopticks6_PM4_PRC-5795_Vdbroucke_27.raw	Raw

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Publications

Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies.

Delvenne Aurore A Vandendriessche Charysse C Gobom Johan J Burgelman Marlies M Dujardin Pieter P De Nolf Clint C Tijms Betty M BM Teunissen Charlotte E CE Schindler Suzanne E SE Verhey Frans F Ramakers Inez I Martinez-Lage Pablo P Tainta Mikel M Vandenberghe Rik R Schaeverbeke Jolien J Engelborghs Sebastiaan S De Roeck Ellen E Popp Julius J Peyratout Gwendoline G Tsolaki Magda M Freund-Levi Yvonne Y Lovestone Simon S Streffer Johannes J Bertram Lars L Blennow Kaj K Zetterberg Henrik H Visser Pieter Jelle PJ Vandenbroucke Roosmarijn E RE Vos Stephanie J B SJB

Fluids and barriers of the CNS 20240718 1

<h4>Background</h4>Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer's disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely unknown. We aim to unravel the relation between ChP functioning and core AD pathogenesis using a unique proteomic approach in mice and humans.<h4>Methods</h4>We used an APP knock-in mouse model, APP<sup>NL-G-F</sup>, exhibiting amyloid pathology, to study the association between AD brain patholo ...[more]

PMID: 39020361

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