Proteomics

Dataset Information

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Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors


ABSTRACT: Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against a panel of kinases, or – preferred – in a complex proteome. Probes that allow photoaffinity-labeling of their targets can facilitate this process. Here, we report photoaffinity probes based on the imidazopyrazine scaffold, which is found in several kinase inhibitors and drugs or drug candidates. By chemical proteomics experiments, we find a range of off-targets, which vary between the different probes.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Skin Cancer

SUBMITTER: Steven Verhelst  

LAB HEAD: Steven Verhelst

PROVIDER: PXD053278 | Pride | 2024-10-28

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F016827_acal.xml Xml
F016828_kira.xml Xml
F016829_lins.xml Xml
aral1-comp.raw Raw
aral1.raw Raw
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