Proteomics

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Of mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

ABSTRACT: - Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, which challenges the fidelity of these models. We employed a quantitative mass spectrometry-based proteomic approach coupled with the generation of patient-specific databases using RNA-seq data to investigate the proteogenomic landscape of serially-passaged PDX models established from two patients with distinct subtypes of ovarian cancer.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary, Peritoneum

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Jesenia Perez  

LAB HEAD: Stefani N. Thomas

PROVIDER: PXD054649 | Pride | 2025-04-07

REPOSITORIES: Pride

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Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer.

Perez Jesenia M JM   Duda Jolene M JM   Ryu Joohyun J   Shetty Mihir M   Mehta Subina S   Jagtap Pratik D PD   Nelson Andrew C AC   Winterhoff Boris B   Griffin Timothy J TJ   Starr Timothy K TK   Thomas Stefani N SN  

Scientific reports 20250104 1

Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, challenging the fidelity of these models. We employed a quantitative mass spectrometry-based proteomic approach coupled with generation of patient-specific databases using RNA-seq data to investigate the p  ...[more]

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