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Combination of Metabolomics, Lipidomics and Molecular Biology to Investigation of Metabolic Disturbance of Short-Term Administration of Emodin

ABSTRACT: To comprehensively elucidate the possible mechanism of short-term administration of emodin on the metabolic disturbance in vivo, our study utilized both LC/MS and NMR platforms for untargeted metabolomics studies. These analyses aimed to identify potential biomarkers associated with emodin-induced metabolic disturbances in mice. Subsequently, we delved into lipidomics to explore lipid metabolism systematically and determined the position of C=C double bonds in unsaturated lipids.

INSTRUMENT(S): Q TRAP, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma, Liver

SUBMITTER: Haitao Wang

LAB HEAD: Lifeng Han

PROVIDER: PXD055000 | Pride | 2024-10-17

REPOSITORIES: Pride

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			Action	DRS
	Emodin-0d-1.raw	Raw
	Emodin-0d-2.raw	Raw
	Emodin-0d-3.raw	Raw
	Emodin-0d-4.raw	Raw
	Emodin-0d-5.raw	Raw

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Combination of Metabolomics, Lipidomics, and Molecular Biology for the Investigation of the Metabolic Disturbance of Short-Term Administration of Emodin.

Wang Haitao H Mao Rui R Wang Liming L Wang Chenxi C Teka Tekleab T Zhang Zixin Z Choi Shin Sik SS Fu Zhifei Z Han Lifeng L

Journal of proteome research 20240916 10

Emodin, a natural anthraquinone derivative, is an active ingredient in many Chinese traditional herbs. Interestingly, although it is generally considered to possess hepatoprotective activity, some studies have also reported that it has a certain degree of hepatotoxicity. Additionally, the underlying metabolic regulation of emodin remains uncertain. Therefore, we conducted a nontargeted metabolomic study based on UHPLC/Q-Orbitrap-MS and NMR. Data are available via ProteomeXchange with the identif ...[more]

PMID: 39279465

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