Proteomics

Dataset Information

0

Proteome of wild type and Nsun7 knockout mice testis


ABSTRACT: Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal columns of the fibrous sheath. The whole testis proteomes of wild type and Nsun7 knockout mice were obtained to study the molecular pathways affected by NSUN7.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

DISEASE(S): Infertility

SUBMITTER: Ekaterina Guseva  

LAB HEAD: Petr Sergiev

PROVIDER: PXD057007 | Pride | 2025-03-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
210422_I2_01.raw Raw
210422_I2_01_20220422201014.raw Raw
210422_I2_01_20220422215657.raw Raw
210422_I2_02.raw Raw
210422_I2_02_20220423091403.raw Raw
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