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TMT-based Quantification LNH treated with incomptine A

ABSTRACT: Summary In this project, 2717 proteins were identified. The fold-change cutoff was set when proteins with quantitative ratios above 1.5 or below 1/1.5 are deemed significant.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lymph Node Of Lower Limb, Lymph Node Of Upper Limb, Non-hodgkin Lymphoma Cell Line, Lymph Node

DISEASE(S): Non-hodgkin Lymphoma

SUBMITTER: Normand Garcia Hernandez

LAB HEAD: Normand Garcia Hernandez

PROVIDER: PXD060392 | Pride | 2025-02-27

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	TMT6126.mgf	Mgf
	TMT6126.msf	Msf
	TMT6126.raw	Raw
	TMT6127.mgf	Mgf
	TMT6127.msf	Msf

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Publications

Quantitative Proteomics and Molecular Mechanisms of Non-Hodgkin Lymphoma Mice Treated with Incomptine A, Part II.

García-Hernández Normand N Calzada Fernando F Bautista Elihú E Sánchez-López José Manuel JM Valdes Miguel M Hernández-Caballero Marta Elena ME Ordoñez-Razo Rosa María RM

Pharmaceuticals (Basel, Switzerland) 20250211 2

<b>Background/Objectives:</b> Incomptine A (IA) has cytotoxic activity in non-Hodgkin lymphoma (NHL) cancer cell lines. Its effects on U-937 cells include induction of apoptosis, production of reactive oxygen species, and inhibition of glycolytic enzymes. We examined the altered protein levels present in the lymph nodes of an in vivo mouse model. <b>Methods:</b> We induced an in vivo model with Balb/c mice with U-937 cells and treated it with IA or methotrexate, as well as healthy mice. We deter ...[more]

PMID: 40006055

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