Project description:16HBE cells were incubated for 3 or 6h with a homeopathic preparation of Drosera r. or the solvent control and the transcriptome was analyzed by RNA sequencing. The expression changes of the main statistically significant genes were validated through follow-up experiments using RT-qPCR. Compared with the control solution, Drosera r. changed the expression of dozens of genes already after 3h and this effect was amplified after 6 hours of treatment. The main target genes were some ligands of epithelial growth factor receptor (EREG, AREG, EPGN), genes involved in xenobiotic detoxification (CYP1B1, TIPARP) and chemokines. The network of the main biological functions included epithelial cell proliferation, regulation of angiogenesis, cell chemotaxis, and wound healing. Drosera r. acts on a complex and faceted set of genes, potentially involved in different layers of the bronchial mucosa. The global effect of the plant in 16HBE epithelial cells is a mild stress response that primes the epithelial reparative process and recruits the innate cell defense.

2021-02-02 | GSE144215 | GEO

Drosera rotundifolia induces gene expression changes in human bronchial epithelial cells 16HBE

Project description:Drosera rotundifolia induces gene expression changes in human bronchial epithelial cells 16HBE

| PRJNA603072 | ENA

Reevesia rotundifolia isolate:Reevesia rotundifolia

Project description:Reevesia rotundifolia Genome sequencing and assembly

| PRJNA740054 | ENA

Drosera spatulata strain:common

Project description:Genome and transcriptome of Drosera spatulata

| PRJDB9009 | ENA

Drosera regia

Project description:Drosera regia Genome