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Mouse gut metagenome

ABSTRACT: Microbial diversity in adenine-induced renal failure mice.

PROVIDER: PRJDB7524 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR153228_1.fastq.gz	Fastqsanger.gz
	DRR153228_2.fastq.gz	Fastqsanger.gz
	DRR153229_1.fastq.gz	Fastqsanger.gz
	DRR153229_2.fastq.gz	Fastqsanger.gz
	DRR153230_1.fastq.gz	Fastqsanger.gz

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Project description:Microbial diversity in adenine-induced renal failure mice with SGLT1 inhibitor treatments.

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Project description:Linaclotide reduced the TMAO level ameliorating cardiac fibrosis in an adenine-induced CKD model

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Quantitative proteomics analysis of five mouse models with chronic kidney disease

Project description:To investigate the proteome changes in the renal cortex of five CKD mouse models, we performed TMT-based quantitative proteomics on these five models and their respective controls. The five models are: 5/6 nephrectomy (Set1, 8 controls and 8 CKD mice), adenine diet 2 weeks (Set2, 6 controls and 6 CKD mice), adenine diet 4 weeks (Set3, 6 controls and 6 CKD mice), unilateral ischemia-reperfusion (IRI, Set4, 9 controls and 8 CKD mice), and nephrotoxic nephritis (NTN, Set5, 7 controls and 8 CKD mice).

2023-01-24 | MSV000091124 | MassIVE

Project description:Stewed Rhubarb decoction ameliorates adenine-induced chronic renal failure in mice by regulating gut microbiota dysbiosis

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RNAseq of kidneys from a mice model of chronic leptospirosis infection and induced a secondary nephrotoxic injury by adenine feeding

Project description:Background The mysterious chronic kidney disease is multifactorial causes. One of the risk factors is leptospirosis, a re-emerging infectious disease caused by Leptospira spp., for endemic leptospirosis tend to coincide with high-incidence regions of chronic kidney disease of unknown etiology. This study aims to investigate the role of leptospirosis as an emerging culprit in which chronic subclinical kidney injury, may predispose to progressive kidney disease when superimposed on secondary nephrotoxic injury. Methods Adenine-induced renal injury in chronic leptospira-infected C57/BL6 mice were studied for evaluating the renal function, histology and gene expression changes. We employed RNA sequencing-based renal transcriptome to investigate pathogenic pathways associated with secondary nephrotoxic injury in chronic kidney injury due to leptospirosis. Results The severity of kidney lesions was increased and the expression of immune/inflammation/fibrosis genes were significantly up-regulated in either low-dose (0.1%) and high-dose (0.2%) adenine-induced renal injury superimposed on infected mice. Whole renal transcriptome analysis reveals that the substantial amplification of the tremendous amount of expressed genes and fibrosis-related pathways was found in adenine-induced kidney injury add-on to leptospira-infected mice which correlated with kidney dysfunction and fibrosis compared to infection or adenine itself. A total of 41 differentially expressed genes associated with fibrosis were identified in infected mice fed with adenine, suggesting that these potential genes contributed to aggravated renal progression occurred in adenine-fed chronic leptospira-infected mice. Conclusions In summary, this study indicates that chronic subclinical kidney infection when exposed to different degree of secondary nephrotoxic injury may predispose to exacerbated and progressive chronic kidney disease.

2021-04-05 | GSE150641 | GEO

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Project description:Effect of pectic oligosaccharide based synbiotic formulation on dysbiosis mice model gut microbial diversity modulation.

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Project description:Gut microbiota of streptozotocin-induced diabetic mice

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Secondary-Electrospray Ionization Mass Spectrometry-based Online Analyses of Mouse Volatilome Uncovers Gut Microbiome-Dictated Metabolic Changes in the Host

Project description:In this study, mouse microbial populations were depleted using an antibiotic cocktail. The microbiome was reestablished using fecal matter transplant or single-strain bacteria species. Volatile organic compounds emitted from the mice were screened to determine if the diversity of the microbial populations can alter host volatilome.

2023-10-16 | MSV000093123 | MassIVE

Relating human gut metagenome and metaproteome

Project description:Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and shotgun metaproteomics. We found a considerable divergence between genetic potential and functional activity of the human healthy gut microbiota, in spite of a quite comparable taxonomic structure revealed by the two approaches. Investigation of inter-individual variability of taxonomic features revealed Bacteroides and Akkermansia as remarkably conserved and variable in abundance within the population, respectively. Firmicutes-driven butyrogenesis (mainly due to Faecalibacterium spp.) was shown to be the functional activity with the higher expression rate and the lower inter-individual variability in the study cohort, highlighting the key importance of the biosynthesis of this microbial by-product for the gut homeostasis. The taxon-specific contribution to functional activities and metabolic tasks was also examined, giving insights into the peculiar role of several gut microbiota members in carbohydrate metabolism (including polysaccharide degradation, glycan transport, glycolysis and short-chain fatty acid production). In conclusion, our results provide useful indications regarding the main functions actively exerted by the gut microbiota members of a healthy human cohort, and support metaproteomics as a valuable approach to investigate the functional role of the gut microbiota in health and disease.

2017-07-19 | PXD005780 | Pride

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